Technology had improved a lot in the last few decades and hence now we are experiencing the best gift from it especially in the health ground. Women’s fertility had always remained a serious issue since the evolution of life on this unique planet and since then scientists are working continuously to bring them back from this depression. It may sound too simple to those who can reproduce easily but it is a serious issue for those who cannot do it.
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Causes of female infertility
The main causes of female infertility include psychogenic factors, ovulatory failure (endocrine sterility, 35-40%), tube-peritoneal factor (20-30%), various gynecological diseases (15-25%) and immunological causes (2%).
Anovulatory infertility can be caused by injury at any level of the reproductive system. The most common causes of anovulation: hyperandrogenism, hyperprolactinemia, hypoestrogenia, metabolic disorders (obesity, a pronounced deficit of body weight), as well as disease of Cushing’s syndrome, hypo-and hyperthyroidism.
Development and improvement of modern methods of fertility treatments, involving violation of the ovulation process, remains an important problem in gynecologic practice. In recent decades a leading role in the treatment of anovulatory infertility, have taken gonadotropins, having a sufficiently high clinical efficacy in treatment – 30-80% of pregnancies.
Clomid is one of the known gonadotropins and is used in the treatment of anovulatory infertility in women, amenorrhea, galactorrhea, oligospermia, and in other cases.
What is Clomid?
Clomid could be described as a top remedy to all those couples who are facing this problem. It is expected that with the developing technology soon it will be a past issue. It is involved with the induction of ovulation. It is not the complete name of the medicine. The complete name of Clomid is Clomiphene citrate and you can only obtain it after having a prescription from the doctor. It is known to stimulate the process of evolution among females and increase the possibility of conceiving. It is one of the best solutions ever provided to the victim of infertility and works as an anti-depression dote against those who are missing everything in their life due to infertility.
Clomid is an oral non-steroidal drug which is prescribed as monotherapy or combined treatment of female infertility caused by:
– chronic anovulation;
– anovulatory ovarian dysfunction;
– polycystic ovary syndrome (Stein-Leventhal syndrome);
– violation of ovulation when failure of the hypothalamus;
– oligomenorrhea or secondary amenorrhea of various origins;
– dysfunctional uterine bleedings.
Clomid belongs to so called fertility drugs — medications that are used to influence ovulation.
Pharmacological properties of Clomid for women:
– it can bind to estrogen receptors in the hypothalamus and ovaries;
stimulate the activity of the endocrine glands;
– increase the secretion of prolactin, follicle-stimulating and luteinizing hormone;
– reduce the level of circulating estrogen;
– stimulate the development of the yellow body and cause ovulation.
The drug Clomid has a high degree of pharmacological activity, and therefore it is prescribed for conduction of a short course of treatment of female infertility, the duration of which should not exceed 5 days. When there is the need for re-treatment of ovulatory infertility, after using the last dose of the drug Clomid should take at least 30 days.
About the active substance of the Clomid
Clomid rarely has side effects for both men and women. As a rule, it can only be a temporary increase in temperature (rush of blood), blurred vision (mist in front of the eyes), more rarely nausea, dizziness, and headaches. Also, from the side of CNS, a short-term depression increases excitability, and insomnia can occur.
Women are more sensitive to changes in the content of estrogen in the body, so they are more often complaining of side effects. Women also may have cystic enlargement of the ovaries, and, rarely increased urination, dysmenorrhea.
Blocking the action of estrogen in the body, Clomid stimulates the ovulation process, whereby the drug is recommended for women suffering from infertility in secondary ovarian hypofunction, or to improve their ability to fertilize. In addition, the drug increases the concentration of estradiol in the blood and can be used in the absence of menstruation in women or their weak and scanty flow.
Clomid also promotes burning fat and increasing muscle mass, especially in “difficult” areas in women, like the hips and lateral surface.
No medicine in the world is available in the world without side effects and Clomid is one among them. Although no doubt the side effects compared to other product is too low. You may come across problems such as the swing of mood, fatigue, headache, vomiting, nausea, etc but the possibility of these symptoms is too low. You may or may not come across them.
Some scientists may associate it with certain serious issues such as liver and kidney problems, ovary twisting; fluids in the stomach, etc. It can be used along with a medicine called Metformin for better results. Metformin is also one of the medicines which fight against infertility but not as good as Clomid. Till now the successful rate of Clomid is 22.5%. It is no doubt the best among the medicine for treating infertility.
Possible Clomid side effects and interferences with other drugs
Before taking clomiphene check if you have any of the following diseases, as your treatment may not be compatible with them: blood vessel diseases or blood clots, ovarian cysts, liver diseases, ovarian cancer, pituitary gland disease, vaginal bleeding outside the cycle, allergic reactions to clomiphene, other drugs, dyes, or preservatives, etc. Also, if you are already pregnant you should avoid taking the medicine, as well as if you are breastfeeding.
Although safe to use, and without requiring any medical prescriptions, clomiphene can cause a handful of allergic reactions and side effects. The most common side effects include breathing difficulties, ovarian enlargement, and pelvic pains, headaches, flushing, nausea, vomiting, diarrhea, breast discomfort, foggy vision, or out of the ordinary uterine bleeding. Closing your throat, swelling of your lips, and tongue represent stronger side effects which, if occurred, you should immediately contact a doctor.
Also, ovarian hyper-stimulation syndrome (OHSS) was reported in patients undergoing clomiphene and can be dangerous to your health, and may even cause death. If you experience any of the side effects related to OHSS notify your doctor. Also bear in mind that this drug increases the likelihood of multiple births, but also the risks usually associated with twin and triplet pregnancies.
How to take?
Keep in mind, before you buy the medication it is demanded to undergo medical examination including you and of your partner/spouse. This is needed to exclude the diseases that can’t be treated by Clomid, such as blocked follicular tubes, or find out the problem is in you but not in your spouse. Also, the examination is needed to help the doctor find out what dose is the best for you. Clomid for infertility should be taken in a dose of 50 milligrams once a day at bedtime. Drug therapy should be started from the fifth day of the menstrual cycle and continued for five days. The dosage also depends on the manufacturer of the medicine and your health status. You need to know about it! Available and recommended Clomid dosages.
If there is not a result of treatment, the dose should be increased to 150 milligrams a day, or take the drug for ten days. The dose of medicine for the treatment should not be higher than 1000mg. It is better to have a pill-taking schedule just to follow it in order not to miss the date when you have to start your therapy. The pills are taken for five days only: either starting from the 3rd or the 5th day of your cycle through 7 and 9 days respectively. If the pills don’t work, tell your doctor about it. It may happen that you will need a larger dose or need to change your protocol.
The clinical efficacy of the drug Clomid to stimulate ovulation
Effectiveness of the drug Clomid in the treatment of female infertility is proved by large-scale clinical studies, which involved 7558 women of childbearing age with ovulatory dysfunction.
The results of clinical trials of the drug Clomid has proved that:
– 71% of women ovulate in 6-12 days after the last dose of Clomid;
– in 26.5% of women, the successful conception of a child takes place after the first five days of treatment ovulatory infertility.
Notable is the fact that using the drug Clomid in women with ovulatory infertility increases the likelihood of multiple births. It should be noted that the use of the drug Clomid for pregnancy helps to achieve the desired result only if the impossibility of conceiving a child is not due to:
– obstruction of the fallopian tubes;
– hormonal disorders (except polycystic ovary syndrome);
– hereditary or acquired endocrine diseases;
– male infertility.
Treating female infertility with Clomid (Clomiphene)
Clomid is available in a regular store but you need to have a prescription for it and on the other hand, there are chances that you have to feel embarrassed while producing the prescription. All these problems can be solved if you buy Clomid online is required and you can easily avail it. Generally, when you order any product, online your identity is kept secret and on the other hand, you can get certain offers or discounts along with it. You can also take the help of online consultancies for suggestions. Always buy Clomid from reliable sources, so that you are sure to have good quality products. Some companies also offer services such as pay after delivery. You do not need to spend endless hours visiting one shop to another or no need to wait in queues anymore, you are just required to order it online and it will be available at your doorstep. You can also compare the prices of related products and in case, if you have any doubts regarding its usage you can take the help of online consultancy at any point in time.
When asked what is the most known medication for infertility you will find this is Clomid. The reason it is so popular is that it works in 80% of cases. Also, the fact that it is less expensive than other fertility medications adds to Clomid popularity. Clomid pills costs less yet are very effective and are normally the first medication prescribed by your doctor if you are diagnosed with the ovulatory disorder. In many cases, it is used as an alternative to IVF treatment, which is very costly and won’t suit a person on a tight budget.
To keep with the topic of Clomid cost, it should be said that you will pay less than you expect if you decide to opt for generic drugs. Normally Clomid cost is covered by your medical insurance or at least you have to pay half of a price, which usually varies from $50 to $70 for a brand Clomid. So you see that Clomid cost without insurance can be rather high. That is the case when generic Clomid is preferred to brand drug due to its high efficiency and affordable price so that in hard times like these Clomid can be a real salvation for a couple of longing for a baby.
The cost of Clomid can also vary due to the size of the pack you choose. When bought in a bundle it will save you even more money. This medicine is prescribed to be taken in cycles, so if you prefer to have a whole amount of pills needed for the whole course of therapy (not more than 6 cycles), it will be beneficial for your pocket as well as for your health. So you should not be frightened when you are told you have an ovulation disorder and ask “How much does Clomid cost?” in despair. What you need is to weight all pros and cons of the drugs offered on the market to make the right choice. Even if you have any problems with your insurance and you so badly need to start your treatment, you can find out what the cost of Clomid without insurance is either over the internet or at your local drugstore. This will help you decide on the medication that will satisfy your needs and purse in the most efficient way.
To sum up, Clomid was created to give more women a chance to experience the joy of motherhood in their life, to give a gift they deserve to have – tiny human cuddling in the arms. And the cost of the treatment, in this case, is the last thing to bother you because there is always a choice of drug you can afford to buy.
Dr. Frank Silver, gynecologist
Clomid or Clomiphene represents one of the many fertility drugs women are usually prescribed in order to help women properly ovulate during their cycle. By taking the drug women to increase their chances of getting pregnant, and even have multiple babies in one pregnancy (twins, triplets). In fact, 5 out of 100 in my patients who take Clomid have twins. The drug works by stimulating the number of hormones supporting growth by releasing a mature egg during ovulation.
Before starting any treatment with Clomid I recommend to run a complete set of tests to check possible allergies or incompatibilities. Depending on your problem, age, or medical background I will prescribe you the exact amount of Clomid pills to take, as well as the duration of the treatment. Usually, women fighting infertility problems using Clomid take the drug for five days during each month’s ovulation, which increases their chances to remain pregnant.
There are different concentrations found in Clomid pills, ranging from 25 mg/pill to 100 mg/pill. I will also be the one prescribing the exact concentration suitable for your treatment. Try taking your pills regularly at approximate hours each day. If you skip a dose you should take it as soon as possible when you remember. However, if your next dose approaches more rapidly, do not ingest a double dose of the Clomid (meaning two pills at once).
Diana, 36 y.o.
I designed my first child unexpectedly when I was 17, but once it came time to try out for the number of children we had two problems. I developed PCOS and not have a menstrual cycle for 8 months in a row (due to anovulation) so my doctor prescribed Clomid after 18m of bad luck. I took 50 mg on days 2-6 of the cycle and conceived my baby on the 14th day of the cycle (April 2018). He was born at 37 weeks at 110% healthy. When we decided to try my 3 I have my doctor prescribed Clomid again immediately, which allows us to avoid unnecessary stress groped no luck again. We then used the 50mg cycle days 1-5 and this time I drew my beautiful little girl, the 21 days of the cycle, the first new cycle (September 2019). He was born at 39 weeks, 10 pounds of perfection. Clomid was my miracle.
Carry, 28 y.o.
My husband and I were trying to get pregnant four years ago and has never happened to us. We finally decided to try again. After talking with my doctor put me on metformin and Clomid. The only side effect I had was a Clomid hot flashes, and that’s all. After taking my first dose of 50 mg 5-9 days, I discovered I was pregnant! This is our first child. We went through a negative pregnancy test before and many of their heartbroken each time. So for you ladies out there reading this and you think that will not happen. It can happen. God blessed them, and we bless you!
Lilly, 29 y.o.
My husband and I knew we wanted to create a family when we got married… We had no idea until then that it would be difficult to find. After about 6 months of unsuccessful attempts, I made an appointment with my doctor. My doctor referred me to a fertility clinic and Dr. Frank Silver took us under his wing. I discovered that I had cysts all over both of my ovaries and my right ovary was enlarged. Dr. Silver was immediately scheduled for surgery and removed the cyst. Then I started taking Clomid 150 mg daily for 5 days every month and I found out I was pregnant within 5 months later. Our son Payton is 2 1/2 years, and we could not be happier! For those out there going through this… frustrated, do not give up! At least when you expect it, your little miracle will be com. Remember that the success story emphasizing each month puts another obstacle in your way. Love one another and have faith that one-day little miracle.